Phylogenomenclature (P-Gnome)
Links:

CAOS

In an ideal world, a full phylogenetic analysis would be done on every new sequence found. However, this is often a time and computer-intensive task. Phylogenomenclature (P-Gnome) is a method to approximate a parsimony-based tree analysis. It important to emphasize that P-Gnome is NOT a tree analysis, instead it is a classification scheme based on a phylogenetic analysis. Based on information (rules) discovered from the phylogenetic analysis that unambiguously distinguish between each bifurcating node on a tree, P-Gnome is able to classify novel sequences. Preliminary studies have indicated that P-Gnome-based classification has over a 99% accuracy rate of classification,as determined by where sequences would be classified if a full phylogenetic analysis were to be done using the novel and known sequences.

P-Gnome is primarily driven by a Columbia University Patent Pending Algorithm, CAOS. CAOS is rooted in some of the tenets of information theory and is generalizable to any type of organized discrete data.

Phylogenomenclature in action:

  • NTPase Classification
  • Homeobox Classification
  • Primary Developers:

    Indra Neil Sarkar

    Paul J. Planet

    Joseph Thornton

    Rob DeSalle

    David Figurski